Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Electrodiagnostic study of the neurotoxicity of methyl n-amyl ketone.

Authors
Johnson-BL; Setzer-JV; Lewis-TR; Hornung-RW
Source
Am Ind Hyg Assoc J 1978 Nov; 39(11):866-872
NIOSHTIC No.
00083589
Abstract
An electrodiagnostic study to determine the neurotoxicity in animals of methyl-n-amyl-ketone (110430) (MAK) is reported. Eight monkeys and 50 rats in each of the two groups were exposed to MAK at 100ppm and 1000ppm for 6 hour a day, 5 days a week, for 9 months. Electrodiagnostic methods revealed no measurable signs of neurotoxicity in the animals at either MAK exposure, and no changes in body weights. Gross pathology and histopathology indicated no adverse effects of MAK. It was concluded that MAK does not possess the neurotoxic properties found in methyl-n-butyl-ketone (591786).
Keywords
NIOSH-Author; Ketones; Physiology; Chronic-toxicity; Exposure-limits; Air-contamination
CODEN
AIHAAP
CAS No.
110-43-0; 591-78-6
Publication Date
19781101
Document Type
Journal Article
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Issue of Publication
11
ISSN
0002-8894
Source Name
American Industrial Hygiene Association Journal
TOP