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Silica dust inhalation and resistance to infections.

Authors
Zarkower-A; Ferguson-FG
Source
NIOSH 1978 May; :1-120
Link
NIOSHTIC No.
00082926
Abstract
To determine the effects of silica (7631869) dust inhalation on the immunological defense mechanisms which are involved in pulmonary resistance to infection, mice were housed in exposure chambers and subjected to various concentrations of silica dust for various lengths of time; control mice were similarly housed without exposure to silica dust. These exposures were followed by examination of a variety of immunologic responses and morphological studies of tissue. There was a very severe reduction in the numbers of antibody forming cells in spleens and mediastinal lymph nodes after aerosol administration of antigens. There was decreased phagocytic activity of lung macrophages and decreased lung clearance of inhaled bacteria. There was a decrease in the antigen processing ability of lung derived macrophages, and a decreased response to antigens of spleen cells from silica exposed animals used to repopulate gamma irradiated syngenetic recipients. There were progressive cellular changes in the lungs including early infiltration of chronic inflammatory cells, followed by the development of silica containing macrophages, and after 39 weeks of exposure, the presence of silica associated fibrotic nodules both in the lungs and in the mediastinal lymph nodes. It is concluded that mice exposed in this manner serve as excellent models for further study of the pathogenesis of diseases caused by inhalation of other toxic substances besides silica.
Keywords
NIOSH-Publication; Immunology; Analytical-methods; Dusts; Pulmonary-system-disorders
Contact
Veterinary Science Pennsylvania State University 102 Animal Industries Bldg University Park, PA 16802
CAS No.
7631-86-9
Publication Date
19780501
Document Type
Final Grant Report
Funding Amount
75435
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
PB88-240155
NTIS Price
A07
Identifying No.
Grant-Number-R01-OH-00538
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Center for Air Environment Studies, Pennsylvania State University, University Park, Pennsylvania, NIOSH Grant No. R01-OH-00538, 120 pages, 39 references
State
PA
Performing Organization
Pennsylvania State University Park, University Park, Pennsylvania
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