Chemical and statistical studies of contaminants in urban lungs.
Sweet-DV; Crouse-WE; Crable-JV
Am Ind Hyg Assoc J 1978 Jul; 39(7):515-526
Lungs taken at autopsy from 100 urban residents were studied to determine concentrations of 21 trace metals, dust, free silica (7631869), and hydroxyproline (51354). Medical, occupational and environmental histories were collected so that correlation studies might be performed. The potential value of this data as a baseline for further studies of occupationally diseased lung tissue was assessed by analysis of variance. The personal histories were used as the criteria for classifying the observations (lung concentrations) into groups for the statistical analysis. Analytical data for dust, hydroxyproline, and trace metals were compared to earlier coal miner studies. Dust levels were comparable to miners dust levels, but the dust itself was of a different composition from one group to the other. Free silica mean concentrations were lower by a factor of 10 in the urban group, while no differences were detected in hydroxyproline levels. The magnitude of the significant differences among group means found indicate the potential value of this urban data as a baseline in an analysis of coal miner data. It is considered desirable in future analyses of data for coal miners to be able to make comparisons with controls without consideration of historical factors.
NIOSH-Author; Physiology; Pulmonary-system-disorders; Coal-workers-pneumoconiosis; Air-contamination; Lung-disorders
American Industrial Hygiene Association Journal