Pulmonary-hematologic studies on humans during exposure to methylene chloride.
Forster-HV; Graff-S; Hake-CL; Soto-R; Stewart-RD
NIOSH 1974 Apr; :1-18
In order to determine whether daily exposure to methylene chloride (75092) vapors affects hemoglobin affinity for oxygen and/or pulmonary function, four healthy young males aged 22 to 24 years were exposed for 7-1/2 hours per day for 26 days in an environmental chamber over 6 consecutive weeks to various concentrations (0 to 50ppm) of methylene-chloride vapor. Effects of the vapor on pulmonary airways, pulmonary gas exchange, the regulation of pulmonary ventilation and hemoglobin affinity for oxygen were examined. There was no perceptible effect on the first three categories, but the increased saturation of hemoglobin with carbon- monoxide (124389) during exposure to methylene-chloride did increase hemoglobin affinity for oxygen. There was no adaptation during exposures to restore hemoglobin affinity for oxygen to normal. Reproducibility of this method is plus or minus 5%.
NIOSH-Contract; Contract-099-72-0084; Chlorinated-hydrocarbons; Chloromethanes; Organic-solvents; Dichloromethane; Lung-ventilation; Humans; Hemoglobin-interactions
Final Contract Report
NTIS Accession No.
National Institute for Occupational Safety and Health
The Medical College of Wisconsin, Department of Environmental Medicine