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Electromotive interactions of metals in asbestos carcinogenicity.

Authors
Sunderman-FW Jr.
Source
University of Connecticut School of Medicine, Farmington, Connecticut 1975 Oct:44 pages
Link
NIOSHTIC No.
00080944
Abstract
An investigation into the carcinogenicity of metallic dusts, manganese (7439965) (Mn), chromium (7440473) (Cr), aluminum (7429905) (Al), nickel-sulfide (1344496) (NiS), nickel-carbonyl (13463393), and iron carbonyl-(13463406) was performed. Intrarenal (i.r.) injection of nickel-subsulfate (7786814) (Ni3S2) was found to induce erythrocytosis in Fischer-rats. A single i.r. injection at 5 dosage levels from 0.6 to 10mg/rat caused erythrocytosis to develop reaching a maximum at 2 to 3 months. Blood erythrocyte counts returned to normal by 7 months. No significant changes occurred in leukocyte or platelet counts. Marked erythroid hyperplasia was present in bone marrow of rats that received i.r. Ni3S2, but not in controls or in rats that received i.m. Ni3S2. This study establishes the time response and dose response relationships for Ni3S2 induction of erythrocytosis in rats. Studies into the effects of Mn on tumorigenesis of Ni3S2 indicate that concurrent administration of Mn did not affect the local retention of Ni derived from Ni3S2. This study is consistent with the hypothesis that Mn may antagonize Ni (7440020) inhibition of RNA polymerase activity in rhabdomyocytes.
Keywords
NIOSH-Contract; Contract-099-72-0024; Transition-metals; Nickel-compounds; Heavy-metals; Particulates; Carcinogenesis; Blood-disorders; Animal-models; Experimental-methods
CAS No.
7439-96-5; 7440-47-3; 7429-90-5; 1344-49-6; 13463-39-3; 13463-40-6; 7786-81-4; 7440-02-0
Publication Date
19751001
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1976
NTIS Accession No.
PB82-152943
NTIS Price
A04
Identifying No.
Contract-099-72-0024
Source Name
University of Connecticut School of Medicine, Farmington, Connecticut
State
CT
Performing Organization
University of Connecticut School of Medicine
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