Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Chloro ethers -- occupational carcinogens, a summary of laboratory and epidemiology studies.

Authors
Nelson-N
Source
NIOSH 1975 Jun; :1-22
Link
NIOSHTIC No.
00080684
Abstract
The relationship between chemical structure and carcinogenicity of a group of chloroethers is briefly reviewed, with data summarized from an extensive series of studies at the New York University Institute of Environmental Medicine on the chloroethers. Bis(chloromethyl)ether (542881) (BCME) and its monofunctional analog, chloromethyl-methyl-ether (107302) (CMME) produce tumors in subcutaneous tissue and skin in rodents. BCME is a highly potent vapor carcinogen for the rat lung and for the epithelial sheathing of the nasal nerve. Hydrochloric-acid (7647010) and formaldehyde (50000) can combine to form BCME. The extent of hazard from this combination is unknown. Epidemiologic studies of workers involved in chloroether manufacture have led to the identification of 34 cases of lung cancer in the United States and 13 in Europe. Active but less potent chloroethers have been identified in municipal drinking water in the United States.
Keywords
NIOSH-Contract; Contract-210-75-0062; Ethers; Halogenated-hydrocarbons; Carcinogens; Toxic-substances; Carcinogenesis; Respiratory-irritants; Respiratory-system-disorders; Skin-neoplasms; Epidemiology; Chemical-manufacturing-industry; Chemical-industry-workers; Lung-neoplasms
CAS No.
542-88-1; 107-30-2; 7647-01-0; 50-00-0
Publication Date
19750601
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1975
NTIS Accession No.
PB83-115352
NTIS Price
A03
Identifying No.
Contract-210-75-0062
Priority Area
Respiratory-system-disorders
Source Name
NIOSH, Cincinnati, Ohio
State
NY; OH
TOP