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Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice.

Authors
Kane-LE; Alarie-Y
Source
Am Ind Hyg Assoc J 1977 Oct; 38(10):509-522
NIOSHTIC No.
00077066
Abstract
Mice were exposed to various concentrations of formaldehyde (50000) or acrolein (107028). Concentration response relationships were developed by measuring percent decreases in respiratory rate, indicating upper respiratory tract sensory irritation. Relationships are presented between the concentration associated with a 50% respiratory decrease and the threshold limit value (TLV). A summary of other animal inhalation studies is presented. The bases for the acrolein and formaldehyde TLVS are reviewed. Mice exposed for 4 days showed increasing sensitivity daily for both compounds. A reevaluation of the TLVS is suggested. (Grant No. OH-
Keywords
NIOSH-Grant; NIOSH-Publication; Irritants; Aldehydes; Herbicides; Dose-response; Pulmonary-function; Exposure-limits; Standards
Contact
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
CODEN
AIHAAP
CAS No.
50-00-0; 107-02-8
Publication Date
19771001
Document Type
Journal Article
Funding Amount
332059
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00367
Issue of Publication
10
ISSN
0002-8894
Source Name
American Industrial Hygiene Association Journal
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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