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Production of thermophilic actinomycete-hay aerosols for use in experimental hypersensitivity pneumonitis.

Authors
Burrell-R; McCullough-MJ
Source
Appl Environ Microbiol 1977 Dec; 34(6):715-719
NIOSHTIC No.
00077059
Abstract
An investigation of the factors that influence the production of dense aerosols of micropolyspora faeni and thermoactinomyces vulgaris from hay cultures revealed that the density, freshness, and moisture content of the hay were important influences. Dry aerosols were produced under optimum conditions from hay cultures of either actinomycete and from sterile hay for inhalation challenges to unimmunized rabbits. Depressions in arterial oxygen tensions and hemolytic complement were monitored after such challenge. This investigation showed that hay cultures are capable of inciting a hypersensitivity like reaction in the lungs, even in the absence of immunization to the organisms contained within the hay, but the entire hypersensitivity reaction cannot be attributed to m-faeni and t-vulgaris alone. Hay itself or other microbial or chemical components appear to have some heat stable component that possibly contributes to the pathogenesis of the disease. (Grant No. OH-
Keywords
NIOSH-Grant; NIOSH-Publication; Microorganisms; Pulmonary-system-disorders; Pulmonary-function; Aerosols; Hematology
Contact
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
CODEN
AEMIDF
Publication Date
19771201
Document Type
Journal Article
Funding Amount
289015
Funding Type
Grant
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00360
Issue of Publication
6
ISSN
0099-2240
Priority Area
Pulmonary-system-disorders
Source Name
Applied and Environmental Microbiology
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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