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Current intelligence bulletin 19 - 2,4-diaminoanisole (4-methoxy-m-phenylediamine) in hair and fur dyes.

Authors
NIOSH
Source
NIOSH 1978 Jan; :1-7
NIOSHTIC No.
00076384
Abstract
NIOSH recommends that 2,4-diaminoanisole (615054), or 4-methoxy-m- phenylenediamine, and its salts be handled in the work place as if they were human carcinogens. This recommendation is based primarily upon a preliminary analysis of the National Cancer Institute data indicating that rats fed 2,4-diaminoanisole experience statistically significant excess of site specific malignant tumors as compared to controls. Caution is also indicated by NIOSH epidemiologic studies which suggest an elevated incidence of cancer among cosmetologists. Exposures should be limited to as few employees as possible, while minimizing workplace exposure levels with engineering and work practice controls. In particular, skin exposures should be avoided.
Keywords
NIOSH-Author; NIOSH-Current-Intelligence-Bulletin-No-19; Carcinogens; Oxidizers; Industrial-hygiene; Epidemiology; Cosmetics-workers; Chemical-industry-workers; Animal-products-workers; Amines; Toxicology; Hairdressers; Occupational-diseases; Safety-measures; Control-methods
CAS No.
615-05-4
Publication Date
19780113
Document Type
Numbered Publication; Current Intelligence Bulletin
Fiscal Year
1978
NTIS Accession No.
PB-277266
NTIS Price
A02
Identifying No.
(NIOSH) 78-111; CIB 19
Source Name
National Institute for Occupational Safety and Health
State
OH
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