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Organic Anhydrides Occupational Hazards.

Authors
Anonymous
Source
NIOSH 1977 Oct:241-250
NIOSHTIC No.
00075430
Abstract
The molecular structure, Chemical Abstracts Service number, Registry of Toxic Effects of Chemical Substances number, production figures and economic trends, uses and producer and user data are presented for organic anhydrides, acetic-anhydride (108247), maleic-anhydride (108316), phthalic-anhydride (85449), succinic-anhydride (108305), tetrahydrophthalic-anhydride (85438), trimellitic-anhydride (552307), glutaric-anhydride (108554) and propionic-anhydride (123626). Acute, chronic and subchronic effects of exposure to the various anhydrides are presented. Acetic, maleic, and phthalic anhydrides exert their highly irritating effects on the eyes, skin, and upper respiratory tract with possible injury to the lungs. Succinic-anhydride is reported to be carcinogenic. Skin exposure to acetic-anhydride causes a delayed bulbous dermatitis with desquamation, while exposure to the liquid causes skin burns and serious corneal injury. OSHA recommends threshold limits of 5, anhydrides. The Soviet Union and Czechoslovakia recommended in 1969, threshold limits of 0.2ppm and 1ppm respectively for phthalic- anhydride. A list of reported human occupational exposures to six anhydrides prepared by NIOSH indicates that the largest number of exposures is to phthalic-anhydride, followed by maleic-anhydride. (Contract No. 210-77-0120)
Keywords
NIOSH-Contract; Contract-210-77-0120; Lung-disorders; Respiratory-system-disorders; Physiological-effects; Carcinogens; Skin-disorders; Eye-disorders; Skin-irritants; Exposure-limits;
CAS No.
108-24-7; 108-31-6; 85-44-9; 108-30-5; 85-43-8; 552-30-7; 108-55-4; 123-62-6;
Publication Date
19771001
Funding Type
Contract;
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Contract-210-77-0120
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Source Name
Information Profiles on Potential Occupational Hazards, NIOSH Contract No. 210-77-0120, October 1977
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