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Methyl Chloride Occupational Hazards.

Authors
Anonymous
Source
NIOSH 1977 Oct:29-36
NIOSHTIC No.
00075409
Abstract
This information profile on methyl-chloride (74873) lists its chemical structure, Chemical Abstracts Service number, Registry of Toxic Effects of Chemical Substances number, production figures and economic trends in production, uses, number of companies producing and using the substance, and the biological effects of exposure. The toxic effects of methyl-chloride are believed to result from the methylation of essential enzymes, cofactors, and proteins, thereby rendering them inactive. Acute effects, subchronic effects, and chronic effects are discussed. In mild cases of human poisoning the symptoms include nausea, vomiting, colicky pains and diarrhea. Vertigo, general weakness, blurred vision, drowsiness, and muscle incoordination are also reported. Poisoning also results in hepatic and renal damage along with congestion of the lungs, petechial hemorrhages of pleura, epicardium, and endocardium. The threshold limit value for exposure to methyl-chloride has been set at 100ppm, which is the level recommended by OSHA. (Contract No. 210-77-0120)
Keywords
NIOSH-Contract; Contract-210-77-0120; Toxic-substances; Anesthetics; Explosives; Chlorinated-hydrocarbons; Refrigerants; Chloromethanes; Thresholds; Neuromotor-disorders; Gastrointestinal-system-disorders; Nervous-system-disorders; Eye-disorders; Liver-disorders; Kidney-disorders;
CAS No.
74-87-3;
Publication Date
19771001
Funding Type
Contract;
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Contract-210-77-0120
Source Name
Information Profiles on Potential Occupational Hazards, NIOSH Contract No. 210-77-0120, October 1977
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