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Toxic Evaluation of Inhaled Chlorobenzene (Monochlorobenzene).

Authors
Dilley-JV
Source
NIOSH 1977 Jun:77 pages
Link
NIOSHTIC No.
00075162
Abstract
Male rats and rabbits were exposed to 0, 75, or 250ppm chlorobenzene (108907) vapors for 7 hours daily, 5 days per week, for up to 120 exposure days (24 weeks). Groups of animals from both species were sacrificed after 5 and 11 weeks of treatment and examined for hematology, clinical chemistry, and gross and histopathological changes resulting from the chlorobenzene treatment. A statistical analysis of the data suggests some treatment-related effect on the red cell parameters. There appeared to be a small effect on food utilization in rats. Pathological changes were mostly found in rats, where occasional focal lesions in the adrenal cortex, tubular lesions in the kidneys, and congestion in the liver and kidneys suggested a treatment relationship. The subtle changes observed in rats at 75 and 250ppm suggest that the current maximum permissible concentration for chlorobenzene of 75ppm may be too high and that 5 to 10ppm may be a better working level. (Contract No. 210-76-0126)
Keywords
NIOSH-Contract; Contract-210-76-0126; Chlorinated-benzenes; Kidney-disorders; Toxicology; Liver-disorders; Exposure-limits; Endocrine-system-disorders; Organic-solvents; Genetics; Histopathology; Hepatotoxicity; Nephrotoxicity;
CAS No.
108-90-7;
Publication Date
19770615
Funding Type
Contract;
Fiscal Year
1977
NTIS Accession No.
PB-276623
NTIS Price
A06
Identifying No.
Contract-210-76-0126
NIOSH Division
DBBS;
Source Name
Division of Biomedical and Behavioral Sciences, NIOSH
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