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Occupational exposure to chloromethyl ethers.

Authors
Pasternack-BS; Shore-RE; Albert-RE
Source
J Occup Med 1977 Nov; 19(11):741-746
NIOSHTIC No.
00074833
Abstract
This industry-wide epidemiologic study to evaluate the human carcinogenicity of chloromethyl-methyl-ether (107302) containing the contaminant bis-chloromethyl-ether (542881) included 1827 exposed workers and 8870 controls. Duration and relative intensity of exposure were classified by job description in the personnel records. This information permitted assigning relative magnitude of exposure scores for each job category at several plants, with allowance for temporal changes in the plant processes. Social security records were used for the ascertainment of deaths among separated employees. Death certificates were obtained for virtually all known deaths, and hospital pathology reports were obtained where possible for the cancer related deaths. No differences in noncancer death rates were found. An increased risk of respiratory cancer death in exposed workers was found at only one firm where high exposures are known to have occurred. A clear dose-response relationship with risk ratios exceeding ten for the longest duration and greatest exposure subgroups was demonstrated for this firm. (Contract No. 210-75-0062)
Keywords
JOCMA7; NIOSH-Contract; NIOSH-Publication; Contract-210-75-0062; Dose-response; Chemical-industry-workers; Carcinogens; Hazards; Chemical-manufacturing-industry; Halogenated-compounds; Ethers; Mortality; Lung-cancer; Respiratory-system-disorders
CODEN
JOCMA7
CAS No.
107-30-2; 542-88-1
Publication Date
19771101
Document Type
Journal Article
Funding Type
Contract
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Contract-210-75-0062
Issue of Publication
11
ISSN
0096-1736
Priority Area
Respiratory-system-disorders
Source Name
Journal of Occupational Medicine
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