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Asbestos contamination of parenteral drugs.

Authors
Nicholson-WJ; Maggiore-CJ; Selikoff-IJ
Source
Science 1972 Jul; 177(4044):171-173
NIOSHTIC No.
00073835
Abstract
Fibrous particulates are determined in samples of parenteral drugs obtained during 1969, 1970, and 1971, by optical microscope or electron microscope. The optical determinations are made on one quarter of each sample and the electron-microcope determinations are made on .00001 part of each sample. All 20 drugs analyzed are labeled for intravenous use except three for intramuscular and one for intraperitoneal use. Some fibers in the samples are identified as chrysotile by optical microscopy, while many fibers are asbestos. Although the drug samples represent only a small fraction of those on the market, the results of the analysis should cause concern since finding asbestos fibers in one third of the single vials examined over a year's time indicates significant asbestos contamination.
Keywords
NIOSH-Publication; NIOSH-Grant; Analytical-methods; Foreign-bodies; Contamination; Pollution; Pharmaceuticals; Contaminants; Particulates
Contact
Community Medicine MT Sinai School of Medicine Fifth Avenue and 100 Street New York, N Y 10029
CODEN
SCIEAS
CAS No.
133-21-4; 12001-29-5
Publication Date
19720714
Document Type
Journal Article
Funding Amount
207338.00
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00305
Issue of Publication
4044
ISSN
0036-8075
Source Name
Science
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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