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Modification of an analytical procedure for isocyanates to high speed liquid chromatography.

Authors
Vogt-CR; Ko-CY; Ryan-TR
Source
Environmental Trace Substance Research Center, University of Missouri, Columbia, Missouri 1976 Apr; :1-93
Link
NIOSHTIC No.
00072597
Abstract
The analysis of the industrial isocyanates using high speed liquid chromatography is shown and the advantages of this method over that of the thin layer chromatography counterpart are demonstrated. Minimum detectable limit of 2 nanograms was observed. Linearity up to 1,600 nanograms has been shown on the 25 centimeter Partisil 10 and 5 centimeter Partisil 5 columns. Reproducibility of repeated injections are within experimental errors. Samples are stable for at least 10 days. Column life and efficiency can be preserved by flushing the column daily and minimizing the amount of unreacted nitro reagent injected. Specific compounds that are qualitatively and quantitatively analyzed by the modified method are those generally found in working environments, i.e., 2,4-toluene- diisocyanate (584849); 2,6-toluene-diisocyanate, 4,4'- methylenebis(phenylisocyanate), 1,6-hexane-diisocyanate, and 1,3,5- tris(6-isocyanatohexyl)biuret. (Contract No. 210-75-0052)
Keywords
NIOSH-Contract; Contract-210-75-0052; Analytical-methods; Industrial-chemicals; Toxic-substances; Cyanates; Trace-analysis; Air-quality-measurement; Microanalysis;
CAS No.
584-84-9; 108-19-0
Publication Date
19760401
Funding Type
Contract;
Fiscal Year
1976
NTIS Accession No.
PB-262675
NTIS Price
A06
Identifying No.
Contract-210-75-0052
Source Name
Environmental Trace Substance Research Center, University of Missouri, Columbia, Missouri
State
MO;
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