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Inhibitory effect of manganese upon muscle tumorigenesis by nickel subsulfide.

Authors
Sunderman-FW Jr.; Lau-TJ; Cralley-LJ
Source
Cancer Res 1974 Jan; 34(1):92-95
NIOSHTIC No.
00071940
Abstract
Fischer rats in five experimental groups were given a single injection of penicillin suspension containing carcinogenic dust (2.5 milligrams), alone or in combination with equimolar amounts of aluminum, copper (7440508), chromium (7440473), or manganese (7439965) dusts. Rats in five control groups were treated identically, except that in the intramuscular nickel-subsulfide (12035722) dust was omitted. After 24 months, the incidence of sarcomas at the injection site was 63 percent in the group that received the combination of nickel-subsulfide and manganese dusts, compared with incidences of 96 to 100 percent in the groups that received nickel-subsulfide alone or in combination with aluminum, copper, or chromimum dusts. No sarcomas occurred at the injection site in control groups that did not receive nickel-subsulfide. The finding that the addition of equimolar amounts of manganese dust to nickel-subsulfide dust significantly depresses nickel-subsulfide induced tumorigenesis provides an experimental system for investigations of metal interactions in carcinogenesis (Contract-
Keywords
NIOSH-Publication; NIOSH-Contract; Contract-099-72-0024; Carcinogens; Metal-poisoning; Metals; Nickel; Nickel-compounds; Nickel-sulfides
CODEN
CNREA8
CAS No.
7440-50-8; 7440-47-3; 7439-96-5; 12035-72-2
Publication Date
19740101
Document Type
Journal Article
Funding Type
Contract
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Contract-099-72-0024
Issue of Publication
1
ISSN
0008-5472
Source Name
Cancer Research
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