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Gastrointestinal motor inhibition associated with acute exposure to methyl methacrylate vapor.

Authors
Tansy-MF; Martin-JS; Benhaim-S; Landin-WE; Kendall-FM
Source
J Pharm Sci 1976 Jan; :1-29
NIOSHTIC No.
00071479
Abstract
A mixture of monomeric methyl-methacrylate (80626) vapor in air was delivered into the breathing air of chloralose-urethan anesthetized dogs. Fixed length exposure to 2000ppm doses of the vapor resulted in a transient drop in arterial blood pressure and a marked inhibition of ongoing gastrointestinal motor activities. Motor inhibition always continued for a variable amount of time (on the order of 10 to 15 minutes) subsequent to the cessation of methyl- methacrylate vapor administration. This inhibitory response was not blocked by bilateral vagotomy, spinal transection, or splanchnectomy. It was not blocked by the intravenous administration of tetraethylammonium-chloride (56348). In another series of experiments it was determined that the administration of blood from a dog that was receiving methyl-methacrylate vapor would produce gastrointestinal motor inhibition in another dog that was not connected to the experimental gas mixture. It is therefore concluded that, aside from any reflex effects which might be produced, methyl-methacrylate vapor in sufficient concentration probably exerts a direct inhibitory effect upon gastrointestinal smooth muscle that is mediated by the cardiopulmonary systems. (Grant No. R01-OH-00518)
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Toxic-substances; Anesthetics; Breathing-atmospheres; Acrylates; Gastrointestinal-system; Physiological-response; Muscle-function
Contact
Physiology and Biophysics Temple University 3223 N Broad Street Philadelphia, PA 19140
CODEN
JPMSAE
CAS No.
80-62-6; 56-34-8
Publication Date
19760101
Document Type
Journal Article
Funding Amount
78696
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00518
ISSN
0022-3549
Priority Area
Pulmonary-system-disorders
Source Name
Journal of Pharmaceutical Sciences
State
PA
Performing Organization
Temple University, Philadelphia, Pennsylvania
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