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Neurotoxic properties of certain aliphatic hexacarbons.

Authors
Spencer-PS; Schaumburg-HH
Source
Proc R Soc Med 1977 Jan; 70(1):37-39
Link
NIOSHTIC No.
00071427
Abstract
The importance of chronic testing of potentially neurotoxic compounds in experimental animals is emphasized to describe the range of hexacarbon compounds identified as neurotoxic agents, and to characterize and illustrate the pathological basis for the onset of the nervous system disease. The compounds tested are: n-hexane (110543), methyl-n-butylketone (591786), 2,5-hexanedione (110134), 2,5-hexanediol (2935446), 2,4-hexanedione, 2,3-hexanedione (3848246), and 1,6-hexanediol. Results show that animals chronically intoxicated with these neurotoxic hexacarbons slowly develop a peripheral neuropathy and display concurrent distal nerve fiber degeneration in the peripheral nervous system, and in ascending and descending spinal cord tracts of the central nervous system.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Neurotoxicity; Nervous-system-disorders; Chronic-toxicity; Organic-solvents; Aliphatic-hydrocarbons
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
PRSMA4
CAS No.
110-54-3; 591-78-6; 110-13-4; 2935-44-6; 3848-24-6
Publication Date
19770101
Document Type
Journal Article
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1977
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
1
ISSN
0035-9157
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Proceedings of the Royal Society of Medicine
State
NY
Performing Organization
Yeshiva University, New York, New York
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