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Criteria for a recommended standard... occupational exposure to alkanes (C5-C8).

Authors
Anonymous
Source
NIOSH 1977 Mar; :1-137
NIOSHTIC No.
00071262
Abstract
This report presents the criteria and the recommended standard based thereon which were prepared to meet the need for preventing occupational disease and injury arising from workplace exposure to pentane (109660), hexane (110543), heptane (142825), or octane (111659). The standard is based on the conclusion that acute intoxication by these alkanes involves a transient central nervous system depression and the chronic intoxication may involve a more persistent effect, polyneuropathy. Polyneuropathy has usually been attributed to n-hexane, but exposures to n-hexane alone have not been described. Studies concerning animal toxicity are discussed. Evidence indicates that alkane concentrations needed to produce a physiological response decrease as the number of carbon atoms in the compound increase. However, no data have been reported on health effects from dermal exposure in the workplace and, other than the development of neuropathy, no correlation of environmental concentrations with observed toxic effects has been found.
Keywords
NIOSH-Criteria-Document; NIOSH-Contract; Contract-099-74-0031; Organic-solvents; Toxic-substances; Safety-practices; Reproductive-system; Hydrocarbons; Hazards; Carcinogenesis; Mutagenesis; Nervous-system-disorders
CAS No.
109-66-0; 110-54-3; 142-82-5; 111-65-9
Publication Date
19770301
Document Type
Numbered Publication; Criteria Document
Funding Type
Contract
Fiscal Year
1977
NTIS Accession No.
PB-273817
NTIS Price
A08
Identifying No.
(NIOSH) 77-151; Contract-099-74-0031
Source Name
National Institute for Occupational Safety and Health
State
OH
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