Investigation of alveolar macrophages from rats exposed to coal dust.
Bingham-E; Barkley-W; Murthy-R; Vassalo-C
NIOSH 1975 Jan; :1-14
Rats were exposed to the inhalation of coal dust from either Utah (low prevalence coal workers' pneumoconiosis (cwp)) or Pennsylvania (high prevalence cwp). Rats were number of alveolar macrophages recovered from rats inhaling these two coal dusts (exposures up to four months) was not remarkably different from the number recovered from rats inhaling filtered room air. This is in contrast to results obtained after intratracheal intubation of the dust. The capacity of the lavaged cells to phagocytize and kill bacteria decreased after exposure to either dust. The activity of certain enzymes also decreased. (Grant No. R01-OH-00357)
NIOSH-Grant; Pulmonary-system-disorders; Dust-inhalation; Biological-indicators; Respiratory-system-disorders; Lung-disorders; Enzyme-activity; Host-resistance; Biochemical-responses; Biological-responses; Administration; Immunology
Environmental Health University of Cincinnati Eden and Bethesda Avenues Cincinnati, Ohio 45219
Fourth International Symposium on Inhaled Particles and Vapors, Edinburgh, 22nd to 26th September, 1975, NIOSH Grant No. R01-OH-00357, 14 pages, 11 references
University of Cincinnati, Cincinnati, Ohio