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Initial occupational exposure to lead: chromosome and biochemical findings.

Authors
Forni-A; Cambiaghi-G; Secchi-GC
Source
Arch Environ Health 1976 Mar; 31(2):73-78
NIOSHTIC No.
00071124
Abstract
Serial chromosome and biochemical studies were carried out in 11 subjects before and during initial occupational exposure to moderate quantities of lead (7439921) fumes in a storage battery plant. The rate of abnormal metaphases, mostly with chromatid and one break chromosome aberrations, was approximately doubled after one month of work; it further increased after two months of work; remained in this range up to seven months of exposure; and then tended to decrease somewhat. Blood lead levels increased progressively in the first few months, then reached a steady state. Urinary lead and coproporphyrin levels increased sharply after one month of work, while urinary delta-aminolevulinic-acid (ALA) dehydratase (9036377) (ALAD) activity of red blood cells (RBCs) was reduced to almost 50 percent of the initial values after one month, decreased further in subsequent months, and remained decreased through the remainder of the study. (Grant No. R01-OH-00339)
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Toxic-substances; Heavy-metals; Battery-manufacturing-industry; Workers; Biochemical-responses; Chromosome-damage; Dose-response; Urine-chemistry; Blood-chemistry; Indicators
Contact
None Via S Barnaba, 8 20122 Milan, Italy 20122 Milano, Italy
CODEN
AEHLAU
CAS No.
7439-92-1; 9036-37-7
Publication Date
19760301
Document Type
Journal Article
Funding Amount
25500
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00339
Issue of Publication
2
ISSN
0003-9896
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Archives of Environmental Health
State
ME
Performing Organization
University of Milan, Milan, Italy
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