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Effect of protective agent against lipid-solvent-induced damages: ultrastructural and scanning electron microscopical study of human epidermis.

Authors
Lupulescu-AP; Birmingham-DJ
Source
Arch Environ Health 1976 Feb; 31(1):33-36
NIOSHTIC No.
00071110
Abstract
The ultrastructural and relief (cytoarchitectural) changes of human epidermis following exposure to a protective gel and acetone (67641) or kerosene (8008206) were studied in 5 healthy volunteers. Topical applications of acetone and kerosene on unprotected skin produced cell damage and a disorganized pattern in the upper layers of epidermis. The ultrastructural changes following acetone consisted of large paranuclear vacuoles, swollen mitochondria, and clumped tonofilaments. Severe disorganization with intense cytolysis and enlarged intercellular spaces occurred after exposure to kerosene. Scanning electron microscopy revealed edematous cornified cells (corneocytes) following acetone exposure, whereas kerosene induced the occurrence of large lacunae in the swollen corneocytes. The application of a protective agent (50 percent water, 25 percent glycerin, 10 percent to 15 percent cellulose-methasol gum and 2 percent to 3 percent preservative) prior to solvent exposure substantially reduced the ultrastructural and relief changes of epidermal cells. It is not considered valid to extend these laboratory findings as field tests for workers in chemical factories without further studies from the physiological standpoint. (Grant No. R01-OH-00410)
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Cytopathology; Cell-alteration; Cell-morphology; Cytotoxicity; Histopathology; Skin-disorders; Skin-irritants; Organic-solvents; Fuels; Intracellular-alteration; Skin-protective-agents
Contact
Dermatology Wayne State University 540 East Canfield Street Detroit, Mich 48201
CODEN
AEHLAU
CAS No.
67-64-1; 8008-20-6
Publication Date
19760201
Document Type
Journal Article
Funding Amount
128001
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-000410
Issue of Publication
1
ISSN
0003-9896
Source Name
Archives of Environmental Health
State
MI
Performing Organization
Wayne State University, Detroit, Michigan
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