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Nickel-epidermal interactions: diffusion and binding.

Authors
Samitz-MH; Katz-SA
Source
Environ Res 1976 Feb; 11(1):34-39
NIOSHTIC No.
00070702
Abstract
To elucidate some of the variables associated with nickel (7440020) contact allergy, the diffusion of nickel through the epidermis and the binding of nickel to the epidermis were investigated. Diffusion of nickel-63 through the epidermis from solutions of surfactants was slight. Considerable amounts of nickel, however, were bound to the epidermis. An epidermis powder was prepared, and selected functional groups were inactivated by chemical means. The nickel uptake of these modified epidermis powders as compared to the untreated material indicates that carboxyl groups are involved in the binding of nickel to a greater extent than are amino groups. (Grant No. R01-OH-00303)
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Chemical-binding; Carboxylic-acids; Chemical-groups; Skin-disorders; Metal-poisoning; Hypersensitivity; Permeability; Contact-dermatitis; Heavy-metals; Skin-penetration; Biochemical-reactions
Contact
Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
CODEN
ENVRAL
CAS No.
7440-02-0
Publication Date
19760201
Document Type
Journal Article
Funding Amount
143667
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00303
Issue of Publication
1
ISSN
0013-9351
Priority Area
Dermatitis
Source Name
Environmental Research
State
PA
Performing Organization
University of Pennsylvania, Philadelphia, Pennsylvania
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