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Studies of zinc metabolism in the rat I. Dose-response effects of cadmium.

Authors
Petering-HG; Johnson-MA; Stemmer-KL
Source
Arch Environ Health 1971 Aug; 23(2):93-101
NIOSHTIC No.
00069303
Abstract
Experiments were designed to determine the effects of cadmium (7440439) on zinc (7440666) metabolism in male rats. Zinc is necessary for growth; a one to one ratio of zinc to cadmium in the drinking water inhibits growth, but when the ratio is four to one growth is not affected. Skin disorders were observed in zinc deficient rats with or without cadmium. Body temperature control and copper (7440508) distribution were affected by zinc uptake. Cadmium altered the responses inversely in relation to zinc intake, and can be considered an antimetabolite of zinc, cadmium was localized in the liver and kidneys but not in the testes. There is very little storage of readily available zinc in the male rat.
Keywords
NIOSH-Publication; NIOSH-Grant; Physiological-response; Heavy-metals; Transition-metals; Body-distribution; Antimetabolites
Contact
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
CODEN
AEHLAU
CAS No.
7440-43-9; 7440-66-6; 7440-50-8
Publication Date
19710801
Document Type
Journal Article
Funding Amount
311966
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00337
Issue of Publication
2
ISSN
0003-9896
Source Name
Archives of Environmental Health
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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