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Behavioral and neurological effects of methyl chloride.

Authors
Repko-JD; Jones-PD; Garcia-LS Jr.; Schneider-EJ; Roseman-E; Corum-CR
Source
NIOSH 1976 Dec; :1-215
Link
NIOSHTIC No.
00069068
Abstract
Behavioral and neurological effects on workers exposed to methyl- chloride were evaluated. Seventy three behavioral measures of task performance, four indices of exposure to methyl-chloride, eight indicators of neurological function, a clinical electroencephalogram and demographic data were obtained from 122 workers occupationally exposed to methyl-chloride (74873) at 6 manufacturing plants using the solvent in fabricating processes. The duration of exposure correlated with airborne methyl-chloride, with methyl-chloride on the breath, and with blood hematocrit. Methyl-chloride on the breath also related to airborne methyl-chloride levels, while airborne methyl-chloride and urine acidity correlated with hematocrit. Methyl-chloride levels in ambient air and urine acidity were the two best indicators of workers' performance on behavioral tasks. No significant differences in the presence of abnormal neurological symptoms were noted between experimental and control groups. No significant differences were noted between exposed and non exposed groups with respect to the presence of dysrhythmia. Methyl-chloride adversely affected performance on cognitive time sharing tasks and increased finger tremor. No relation was noted between exposure and psychological or personality tests. (Contract No. 099-74-0020)
Keywords
NIOSH-Contract; Contract-099-74-0020; Chlorinated-hydrocarbons; Urinalysis; Organic-solvents; Physiological-factors; Neurological-disorders; Nervous-system-disorders; Mental-processes; Behavior; Brain-disorders; Blood-chemistry; Cardiovascular-system-disorders; Psychological-factors
CAS No.
74-87-3
Publication Date
19761201
Document Type
Numbered Publication
Funding Type
Contract
Fiscal Year
1977
NTIS Accession No.
PB-274770
NTIS Price
A11
Identifying No.
(NIOSH) 77-125; Contract-099-74-0020
NIOSH Division
DBBS
Source Name
National Institute for Occupational Safety and Health
State
OH
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