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The effect of amosite and chrysotile asbestos on the clearance of TiO2 particles from the lung.

Authors
Ferin-J; Leach-LJ
Source
Environ Res 1976 Oct; 12(2):250-254
NIOSHTIC No.
00068052
Abstract
Techniques were developed to assess the effects of air pollutants on the alveolar clearance pattern of inert particles deposited in the lungs of laboratory animals. Amosite (12172735) or chrysotile (12001295) asbestos exposures, relatively short in duration (1-3 hours) and high in concentration (about 10 milligrams per cubic meter) depressed the alveolar clearance of titanium-dioxide (1309633)) particles in rats. This effect was not observed when asbestos air concentrations were reduced to about 10 times the Threshold Limit Value, estimated to be 0.1 milligrams per cubic meter. Extending the postexposure observation period and the number of exposures to 11 or 22 a suppressive effect on titanium-dioxide clearance was seen. How important this late effect is can not be determined at this time. However, the effect of high concentrations of amosite or chrysotile at exposures lasting only a short time should be considered with concern.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-functions; Respiratory-mechanics; Carcinogens; Asbestos-dust; Lung-clearance; Air-contaminants; Lung-dust-burden; Exposure-limits; Time-dose-relationship; Toxicology; Test-methods
Contact
Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
CODEN
ENVRAL
CAS No.
12172-73-5; 12001-29-5; 1309-63-3
Publication Date
19761001
Document Type
Journal Article
Funding Amount
292984.00
Funding Type
Grant
Fiscal Year
1977
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00334
Issue of Publication
2
ISSN
0013-9351
Priority Area
Pulmonary-system-disorders
Source Name
Environmental Research
State
NY
Performing Organization
University of Rochester, Rochester, New York
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