Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Paint-remover hazard.

Authors
Stewart-RD; Hake-CL
Source
JAMA J Am Med Assoc 1976 Jan; 235(4):398-401
NIOSHTIC No.
00059540
Abstract
The in home use of paint removers containing methylene-chloride (75092) results in the absorption of this solvent, which is metabolized to carbon-monoxide (630080). Exposure for two to three hours can result in the elevation of carboxyhemoglobin to levels that stress the cardiovascular system. The metabolic formation of carboxyhemoglobin continues following the paint remover exposure, doubling the duration of the cardiovascular stress produced by a comparable carboxyhemoglobin level after exposure to carbon- monoxide. Patients with diseased cardiovascular systems may not be able to tolerate this unexpected stress. One case history illustrates the tragedy that can occur when a patient with coronary heart disease is exposed to a paint and varnish remover containing methylene-chloride and the solvent is metabolized to a toxic amount of carbon-monoxide. The second case described in detail is the one in which the in-vivo metabolism of methylene-chloride to carbon- monoxide was first observed.
Keywords
NIOSH-Publication; NIOSH-Contract; Contract-099-72-0084; Toxicology; Organic-solvents; Chlorinated-hydrocarbons; Chlorinated-methanes; Metabolites; Blood-disorders; Cardiovascular-system-disorders
CODEN
JAMAAP
CAS No.
75-09-2; 630-08-0
Publication Date
19760126
Document Type
Journal Article
Funding Type
Contract
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Contract-099-72-0084
Issue of Publication
4
ISSN
0098-7484
Source Name
Journal of the American Medical Association
State
WI
Performing Organization
The Medical College of Wisconsin, Department of Environmental Medicine
TOP