JAMA J Am Med Assoc 1976 Jan; 235(4):398-401
The in home use of paint removers containing methylene-chloride (75092) results in the absorption of this solvent, which is metabolized to carbon-monoxide (630080). Exposure for two to three hours can result in the elevation of carboxyhemoglobin to levels that stress the cardiovascular system. The metabolic formation of carboxyhemoglobin continues following the paint remover exposure, doubling the duration of the cardiovascular stress produced by a comparable carboxyhemoglobin level after exposure to carbon- monoxide. Patients with diseased cardiovascular systems may not be able to tolerate this unexpected stress. One case history illustrates the tragedy that can occur when a patient with coronary heart disease is exposed to a paint and varnish remover containing methylene-chloride and the solvent is metabolized to a toxic amount of carbon-monoxide. The second case described in detail is the one in which the in-vivo metabolism of methylene-chloride to carbon- monoxide was first observed.
NIOSH-Publication; NIOSH-Contract; Contract-099-72-0084; Toxicology; Organic-solvents; Chlorinated-hydrocarbons; Chlorinated-methanes; Metabolites; Blood-disorders; Cardiovascular-system-disorders
Journal of the American Medical Association
The Medical College of Wisconsin, Department of Environmental Medicine