The production of urethane foams and the hazards caused by the chemicals involved are described briefly. The good work practices, ventilation systems, and respiratory protective equipment to be used to prevent excessive exposure are discussed. Safe work practices to protect the skin and respiratory system, and to prevent accidental fires and explosions, are described for foaming operations, spraying and finishing operations. Local exhaust systems are more effective than dilution systems. Respirators are used where proper ventilation cannot be maintained; their use and fitting are described. The handling and storing of isocyanates, the most hazardous components of urethane foams, are described, also the storage of foam, fire precautions, and first aid.