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Early indices of cancer risk among uranium miners with reference to modifying factors.

Authors
Saccomanno-G; Archer-VE; Saunders-RP; Auerbach-O; Klein-MG
Source
Ann NY Acad Sci 1976 May; 271(1):377-383
NIOSHTIC No.
00056889
Abstract
Early indices of cancer risk among uranium (7440611) miners were investigated prospectively since 1957 in a population of uranium miners, via yearly sputum cytology. Autopsies were performed on 120 miners with lung cancer and on 26 miners dying from other causes. The results show that cancer of the lung develops from normal epithelial changes that progress from regular squamous cell metaplasia to progressively more and more atypical stages to eventually develop into squamous-cell carcinoma in situ. The in situ stage sheds large numbers of cells that can often be identified as malignant cells in sputum. This allows early diagnosis, localization, and resection, increasing, it is hoped, survival from bronchogenic carcinoma.
Keywords
NIOSH-Author; Epidemiology; Cancer-process; Respiratory-system-disorders; Diagnostic-tests; Cytopathology; Cell-proliferation; Histopathology; Radioactive-heavy-metals; Medical-treatment; Prognosis; Latent-period
CODEN
ANYAA9
CAS No.
7440-61-1
Publication Date
19760528
Document Type
Journal Article
Fiscal Year
1976
NTIS Accession No.
NTIS Price
ISBN No.
9780890720509
Issue of Publication
1
ISSN
0077-8923
NIOSH Division
DFSCI
Priority Area
Respiratory-system-disorders
Source Name
Annals of the New York Academy of Sciences
State
CO; UT; NJ
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