Mortality patterns among fibrous glass production workers.
Bayliss-DL; Dement-JM; Wagoner-JK; Blejer-HP
Ann NY Acad Sci 1976 May; 271:324-335
Study of mortality patterns among 1,448 workers occupationally exposed to low concentrations of airborne fibers with a median diameter of 1.8 micrometers demonstrates a significant excess of nonmalignant respiratory disease. This excess of nonmalignant respiratory disease is consistent with an earlier report of an increased risk of chronic bronchitis as a cause of retirement disability among fibrous glass production workers. Although the exact contribution of prior employment in dusty trades other than fibrous glass production cannot be completely discounted, several cases of nonmalignant respiratory disease are determined to have had incidental employment in such trades. No excess risk of malignant respiratory disease is demonstrated, even after 20 years since onset of exposure. However, a case-control study among the same population does demonstrate an association of borderline significance between cases of respiratory tract disease (malignant and nonmalignant) and work in pilot plant operations. Some of these operations involve a special process that emits and creates exposures to small-diameter glass fibers. In view of previous demonstrations of fibrogenicity and carcinogenicity of small- diameter glass fibers in laboratory animals, further in-depth studies of the potential pathogenicity (fibrogenicity and carcinogenicity) of small-diameter glass fibers is strongly recommended.
NIOSH-Author; Fibrous-bodies; Respiratory-system-disorders; Fiberglass-industry; Hazards; Physical-properties; Fiberglass; Toxicity; Incidence; Epidemiology
Annals of the New York Academy of Sciences