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Cytologic observations and cancer incidence following exposure to BCME.

Authors
Lemen-RA; Johnson-WM; Wagoner-KJ; Archer-VE; Saccomanno-G
Source
Ann NY Acad Sci 1976 May; 271(1):71-80
NIOSHTIC No.
00056700
Abstract
A hygiene survey was conducted among male employees of an anion- exchange resin production facility using bis(chloromethyl)ether (542881). Those employees with five or more years exposure to bis(chloromethyl)ether, BCME, had a statistically significant association with abnormal sputum cytology, or 34 percent as compared to 11 percent for uranium surface miners. A lung cancer incidence study was made of 136 male workers, 1955-1972; data are given on five cases of bronchogenic cancer. Other studies found similar incidences of lung cancer among BCME workers. Carcinogenicity of BCME was first demonstrated in mice and these results of occupational exposure studies indicate a need for prior animal testing of new chemicals.
Keywords
NIOSH-Author; Diagnostic-techniques; Mortality-data; Toxic-substances; Alkylating-agents; Chlorine-compounds; Carcinogens; Carcinogenesis; Ethers; Screening
CODEN
ANYAA9
CAS No.
542-88-1
Publication Date
19760528
Document Type
Journal Article
Fiscal Year
1976
NTIS Accession No.
NTIS Price
ISBN No.
9780890720509
Issue of Publication
1
ISSN
0077-8923
Source Name
Annals of the New York Academy of Sciences
State
OH; UT; CO
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