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Neurological and Behavioral Toxicology of Increased Lead Absorption.

Authors
Baloh-R
Source
NIOSH 1976 Feb:51-57
Link
NIOSHTIC No.
00056273
Abstract
Neurologic symptoms, illustrated by three case histories, play a prominent part in acute lead (7439921) poisoning and growing evidence suggests an etiologic role of chronic increased lead absorption in several chronic neurologic diseases. A type of motor neuron disease characterized by symmetrical distal muscle wasting, slow progression, and a history of extensive exposure to lead was reported. Although response to chelation therapy was inconclusive, a therapeutic trial of chelation in any patient with motor neuron disease and history of major lead exposure was recommended. Delayed nerve conduction was demonstrated in guinea pigs slowly poisoned with lead acetate (301042), and subsequently, electrophysiologic abnormalities were found in asymtomatic lead workers. Because of these and other similar findings, neurologists and behavioralists are questioning the adequacy of present standards of safe lead absorption.
Keywords
NIOSH-Author; NIOSH-Contract; Contract-210-75-0026; Chronic-toxicity; Behavior; Age-factors; Mental-processes; Nervous-system-disorders; Neuromotor-disorders; Toxicology; Heavy-metals;
CAS No.
7439-92-1; 301-04-2;
Publication Date
19760201
Document Type
Conference/Symposia Proceedings;
Funding Type
Contract;
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
(NIOSH) 76-134
Priority Area
Special Populations; Work Environment and Workforce;
Source Name
Health Effects of Occupational Lead and Arsenic Exposure, A Symposium, NIOSH
State
IL;
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