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Environmental arsenic toxicology.

Authors
Fowler-B
Source
NIOSH 1976 Feb:248-252
Link
NIOSHTIC No.
00056247
Abstract
The mechanisms of inorganic arsenic (7440382) toxicity to cellular respiratory systems are discussed in light of previously reported data and preliminary data from an unpublished study. An electron micrograph is given of a proximal tubule cell from the kidney of a rat exposed to 85 ppm of arsenate, and data are given on respiratory parameters of mitochondria from rats and on arsenic in kidneys of rats given drinking water containing arsenate or arsenite for 14 weeks. Arsenite is shown to accumulate in higher levels in the kidneys than arsenate, which is considered less toxic to cellular respiration. The mechanism of hemolysis by arsine gas is considered related to an oxidized metabolite such as arsenious-acid. It is concluded that the toxicity of inorganic arsenic is highly dependent upon its chemical form and oxidation state.
Keywords
NIOSH-Author; NIOSH-Contract; Contract-210-75-0026; Toxic-substances; Heavy-metals; Kidney-disorders; Biochemical-mechanisms; Biochemical-reactions; Renal-toxicity; Intracellular-alteration; Cytopathogenicity; Metabolism; Pathogenesis; Metabolites
CAS No.
7440-38-2
Publication Date
19760201
Document Type
Conference/Symposia Proceedings
Funding Type
Contract
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
(NIOSH) 76-134; Contract-210-75-0026
NIOSH Division
DSHEFS
Source Name
Health Effects of Occupational Lead and Arsenic Exposure, A Symposium, Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH
State
OH
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