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The Biological Effect of Continuous Inhalation Exposure of 1,1,1- Trichloroethane (Methyl Chloroform) on Animals.

Authors
MacEwen-JC; Vernot-EH
Source
Aerospace Medical Research Laboratory, Wright Patterson Air Force Base, Ohio, Toxic Hazards Research Unit, Annual Technical Report - 1974, AMRL-TR-74-78 1974 Jul:81-90
Link
NIOSHTIC No.
00055677
Abstract
Studies were conducted to evaluate the effects of continuous exposure to 1,1,1-trichloroethane (71556) on hepatic morphology and function of various animals species, and to compare these effects with those produced by methylene-chloride (75092). The findings indicate that both compounds induce similar pathological alterations, except for different time courses of the effects and different degrees of recovery. A ten-fold greater atmospheric concentration of 1,1,1-trichloroethane is required to produce the minimal liver changes found at 100 ppm dichloromethane. This was a joint NIOSH, USAF, and NASA study.
Keywords
NIOSH-Contract; Chlorinated-ethanes; Chlorinated-hydrocarbons; Solvents; Degreasers; Industrial-chemicals; Hepatotoxicity; Liver-disorders; Toxicology; Chlorinated-methanes; Histopathology;
CAS No.
71-55-6; 75-09-2;
Publication Date
19740701
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Source Name
Aerospace Medical Research Laboratory, Wright Patterson Air Force Base, Ohio, Toxic Hazards Research Unit, Annual Technical Report - 1974, AMRL-TR-74-78
State
OH;
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