Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Uptake of mercury and mercury-amino acid complexes by rat renal cortex slices.

Authors
Richardson-RJ; Wilder-AC; Murphy-SD
Source
Proc Soc Exp Biol Med 1975 Apr; 150:303-307
NIOSHTIC No.
00054035
Abstract
The effects of metabolism and complexes with amino acids on the renal uptake of mercury are determined using rat renal cortex slices. Mercury (7439976) levels in the slices after 1 hour of incubation are 50 percent higher with mercuric cysteine than with mercuric-chloride (7487947). The enhanced uptake of mercuric cysteine is reduced in the presence of an excess of lysine (56871) or histidine (71001), with dinitrophenol (51285) present, at 25 degrees or in anaerobic conditions. The uptake of mercuric cysteine is unaffected by serine and increased by cysteine (52904). The metabolic conditions do not affect the uptake of mercuric chloride, suggesting that a portion of the renal uptake of mercury operates through amino acid transport mechanisms acting on mercury-amino acid complexes.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Heavy-metals; Kidney; Nitrophenols; Organo-mercury-compounds; Mercury-compounds
Contact
Physiology Harvard University 665 Huntington Ave Boston, Mass 02115
CODEN
PSEBAA
CAS No.
7439-97-6; 7487-94-7; 56-87-1; 71-00-1; 51-28-5; 52-90-4
Publication Date
19750401
Document Type
Journal Article
Funding Amount
274679
Funding Type
Grant
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00315
ISSN
0037-9727
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Proceedings of the Society for Experimental Biology and Medicine
State
MA
Performing Organization
Harvard University, Boston, Massachusetts
TOP