Aminoaciduria and proteinuria in rats after a single intraperitoneal injection of Ni(II).
Gitlitz-PH; Sunderman-FW Jr.; Goldblatt-PJ
Toxicol Appl Pharmacol 1975 Dec; 34(3):430-440
Proteinuria was found in Fischer female rats after single intraperitoneal injection of nickel (7440020) chloride (7718549) in dosages from 34 to 85 micromoles per kilogram. Generalized alpha- aminoaciduria was found after a single intraperitoneal injection of nickel-chloride in dosages of 68 and 85 micromoles per kilogram. Amino acids in plasma were normal or slightly diminished from 1 to 48 hours after injection of nickel-chloride. Electron microscopy of kidneys of five rats at 48 hour after nickel-chloride (68 micromoles per kilogram) consistently revealed fusion of foot processes of glomerular epithelial cells. Focal tubular necrosis was present in the kidney of one of these rats. This study demonstrates that toxic nephropathy with aminoaciduria and proteinuria develops in rats after intraperitoneal nickel-chloride. Amino acid and protein excretions consistently returned to normal by Day 5.
NIOSH-Publication; NIOSH-Contract; Contract-099-72-0024; Urinary-proteins; Kidney-disorders; Urinary-output; Urine-chemistry; Nephrotoxicity; Heavy-metals; Heavy-metal-poisoning; Nickel-compounds; Cytology
Toxicology and Applied Pharmacology