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Attempts to induce sensitization in guinea pigs with nickel complexes.

Authors
Samitz-MH; Katz-SA; Scheiner-DM; Lewis-JE
Source
Acta Derm Venereol 1975 Oct; 55(6):475-480
NIOSHTIC No.
00053948
Abstract
Sensitization in guinea-pigs is achieved with a nickel alanine conjugate but not with nickel-sulfate (7786814), nickel-alanine, other nickel-amino-acid complexes or with a complex of nickel (7440020) with soluble guinea-pig skin extract. Nickel-amino-acid complexes and nickel guinea-pig skin complex are thus considered not to be antigenic in guinea-pigs with the technique used. Hypothesis for the apparent failure to induce sensitization are proposed.
Keywords
NIOSH-Publication; NIOSH-Grant; Nickel-compounds; Heavy-metals; Alanines; Organo-nickel-compounds; Organo-metallic-compounds; Allergies; Hypersensitivity; Antigens
Contact
Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
CODEN
ADVEA4
CAS No.
7786-81-4; 7440-02-0
Publication Date
19751001
Document Type
Journal Article
Funding Amount
143667
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00303
Issue of Publication
6
ISSN
0001-5555
Source Name
Acta Dermato-Venereologica
State
PA
Performing Organization
University of Pennsylvania, Philadelphia, Pennsylvania
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