Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

An evaluation of the inhalation toxicity of one commercial proteolytic enzyme preparation.

Authors
Richards-DE; Scheel-LD; Groth-DH
Source
Am Ind Hyg Assoc J 1975 Apr; 36(4):266-271
NIOSHTIC No.
00053563
Abstract
The inhalation toxicity of a commercial proteolytic enzyme preparation containing 12% subtilisin Carlsberg was studied in experimental animals. Guinea pigs that had been pretreated by a series of intradermal injections of the enzyme preparations at an air concentration of 41.2 milligrams per cubic meter, while normal guinea pigs and pretreated guinea pigs that were dosed with an antihistamine immediately prior to exposure survived. The 6-hour median lethal concentration for pretreated guinea pigs was determined as 24.7 milligrams per cubic meter. Normal rats, normal rabbits, and pretreated rabbits survived exposures to the enzyme preparation at concentrations as high as 36.8 milligrams per cubic meter. Pathologic examinations revealed changes only in the lungs of the exposed animals. These pulmonary alterations appear to be reversible. A histamine release is suggested as the primary effect of a secondary exposure to this proteolytic enzyme preparation.
Keywords
Toxicology; Dosage; Histopathology; Respiratory-disorders; Lung-disorders; Histamine-liberation; Tissue-reactions; Synthetic-detergents; Housekeeping-products; Industrial-hygiene; Species-susceptibility; NIOSH-Author
CODEN
AIHAAP
Publication Date
19750401
Document Type
Journal Article
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0002-8894
Source Name
American Industrial Hygiene Association Journal
TOP