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Development of sampling and analytical methods for carcinogens.

Authors
Morales-R; Rappaport-SM; Weeks-RW Jr.; Campbell-EE; Ettinger-HJ
Source
Los Alamos Scientific Laboratory, LA-6160-PR Progress Report, UC-41, 1976 Feb; :1-21
Link
NIOSHTIC No.
00052706
Abstract
Activities pertaining to the development of sampling and analytical methods for chemical carcinogens are discussed. A compressed gas nebulizer has been designed to produce respirable, polydisperse aerosols of the aromatic amines on the OSHA list of cancer-suspect agents. The aerosol passes through a sampling chamber which can be maintained at various environments. A two-stage sampling tube incorporating a filter followed by a sorbent is proposed for collecting aerosols and associated vapors from air. High-speed liquid chromatography and gas chromatography have been explored for analyzing these aromatic amines. The former method appears promising for 4,4'-methylene-bis(2-chloroaniline) (101144), benzidine (92875), and 3,3'-dichlorobenzidine (91941); preliminary solvent systems and detection limits are reported. Isomers of phthalaldehyde have been tested for nonspecific field detection of selected aromatic amines on the list. Detection limits are given using these reagents and fluorescamine for amines on various surfaces. Results of glove permeability tests indicate that natural latex and polyvinyl-chloride (9002862) are good materials for protecting skin from contact with various aromatic amines. A chamber is described for testing respiratory cartridges for breakthrough of the carcinogens.
Keywords
IA-74-35; Sampling-methods; Analytical-instrumentation; Aerosol-dispensers; Sampling-equipment; Air-quality-measurement; Air-sampling; Materials-testing; Design; Chromatographic-analysis; Personal-protective-equipment; Skin-protection; Microanalysis
CAS No.
101-14-4; 92-87-5; 91-94-1; 9002-86-2
Publication Date
19760201
Document Type
Interagency Agreement
Fiscal Year
1976
NTIS Accession No.
LA-6160-PR
NTIS Price
A03
Source Name
Los Alamos Scientific Laboratory, LA-6160-PR Progress Report, UC-41, 21 pages, 16 references
State
NM
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