Development of sampling and analytical methods for carcinogens.
Morales-R; Rappaport-SM; Weeks-RW Jr.; Campbell-EE; Ettinger-HJ
Los Alamos Scientific Laboratory, LA-6160-PR Progress Report, UC-41, 1976 Feb; :1-21
Activities pertaining to the development of sampling and analytical methods for chemical carcinogens are discussed. A compressed gas nebulizer has been designed to produce respirable, polydisperse aerosols of the aromatic amines on the OSHA list of cancer-suspect agents. The aerosol passes through a sampling chamber which can be maintained at various environments. A two-stage sampling tube incorporating a filter followed by a sorbent is proposed for collecting aerosols and associated vapors from air. High-speed liquid chromatography and gas chromatography have been explored for analyzing these aromatic amines. The former method appears promising for 4,4'-methylene-bis(2-chloroaniline) (101144), benzidine (92875), and 3,3'-dichlorobenzidine (91941); preliminary solvent systems and detection limits are reported. Isomers of phthalaldehyde have been tested for nonspecific field detection of selected aromatic amines on the list. Detection limits are given using these reagents and fluorescamine for amines on various surfaces. Results of glove permeability tests indicate that natural latex and polyvinyl-chloride (9002862) are good materials for protecting skin from contact with various aromatic amines. A chamber is described for testing respiratory cartridges for breakthrough of the carcinogens.
IA-74-35; Sampling-methods; Analytical-instrumentation; Aerosol-dispensers; Sampling-equipment; Air-quality-measurement; Air-sampling; Materials-testing; Design; Chromatographic-analysis; Personal-protective-equipment; Skin-protection; Microanalysis
101-14-4; 92-87-5; 91-94-1; 9002-86-2
NTIS Accession No.
Los Alamos Scientific Laboratory, LA-6160-PR Progress Report, UC-41, 21 pages, 16 references