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Further studies on the effect of lung antibodies on the pathogenesis of tuberculosis.

Authors
Burrell-R; Lewis-DM
Source
J Lab Clin Med 1975 Nov; 86(5):741-745
NIOSHTIC No.
00052280
Abstract
A study was made to further clarify the role of lung reactive antibodies in tuberculous infection. Following intravenous infection with viable tubercle bacilli, mice received mouse anti- mouse lung antibodies for three weeks. Control groups consisted of tuberculous mice receiving non-lung antibody containing fluid and uninfected mice. A method was developed for quantitating tuberculous infection in these different groups by expressing the number of lesions produced per unit of cross-sectional surface area of the lung. Passive administration of lung antibodies was found to significantly potentiate the number of tuberculous lesions. It was concluded that the antibody in some way lowered the resistance or the tissue to invasion.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Lung-tuberculosis; Infectious-diseases; Immune-reaction; Test-methods; Host-resistance; Tissue-reactions; Pathogenesis
Contact
Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
CODEN
JLCMAK
Publication Date
19751101
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00360
Issue of Publication
5
ISSN
0022-2143
Priority Area
Pulmonary-system-disorders; Respiratory-system-disorders
Source Name
The Journal of Laboratory and Clinical Medicine
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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