Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust.

Authors
Moorman-WJ; Lewis-TR; Wagner-WD
Source
J Appl Physiol 1975 Sep; 39(3):444-448
NIOSHTIC No.
00051718
Abstract
To assess early ventilatory responses at the 2 milligrams per cubic meter bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to Pennsylvania and Utah coal dust. Pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the Utah coal was selected from a low prevalence area. After 24 months of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. Reductions were observed in the forced expiratory volume in 1 second, maximum midexpiratory flow rate, and especially maximum expiratory flow at small lung volumes. Hyperinflation was observed in both coal treatments; however, no specific lung volumes differed significantly from controls. No differences were found between the Pennsylvania and Utah treatments. Design and specifications for a new hydraulically operated plethysmograph-respirator are included.
Keywords
JAPYAA; NIOSH-Author; Fibrosis; Respiratory-system-disorders; Respiratory-function-tests; Measurement-instrumentation; Airborne-particulates
CODEN
JAPHEV
Publication Date
19750901
Document Type
Journal Article
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
8750-7587
Priority Area
Respiratory-system-disorders
Source Name
Journal of Applied Physiology
State
PA; UT
TOP