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Leukocyte recruitment to airways by cigarette smoke and particle phase in contrast to cytotoxicity of vapor.

Authors
Kilburn-KH; McKenzie-W
Source
Science 1975 Aug; 189(4203):634-627
NIOSHTIC No.
00051625
Abstract
The immediate effects of airborne exposure to vapor or particle phase of unfiltered whole cigarette smoke is studied in hamsters. Airways of hamster lungs show recruitment of polymorphonuclear leukocytes after breathing fresh cigarette smoke in a miniature chamber. Exposure to particles alone by removal of the vapor phase with charcoal does not change the leukocyte response. However, exposure to cigarette smoke vapor after removal of particles with Cambridge filters does not recruit leukocytes but produces nuclear and cytoplasmic vacuoles, double nuclei, and exfoliation of cells. The main agents responsible for the vapor toxicity are suggested to be nitrogen-dioxide (10102440) and formaldehyde (50000).
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Smoking; Tobacco-constituents; Cytopathology; Cytotoxicity; Aldehydes; Nitrogen-oxides
Contact
Medicine University of Missouri N424 Medical Center Columbia, MO 65201
CODEN
SCIEAS
CAS No.
10102-44-0; 50-00-0
Publication Date
19750822
Document Type
Journal Article
Funding Amount
230991
Funding Type
Grant
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00511
Issue of Publication
4203
ISSN
0036-8075
Priority Area
Pulmonary-system-disorders
Source Name
Science
State
MO
Performing Organization
University of Missouri Columbia, Columbia, Missouri
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