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Byssinosis: airway responses in textile dust exposure.

Authors
Zuskin-E; Bouhuys-A
Source
J Occup Med 1975 Jun; 17(6):357-359
NIOSHTIC No.
00048392
Abstract
Hemp dust and hemp dust extracts were tested in healthy subjects pretreated with propranolol (318989), ascorbic-acid, and disodium- cromoglycate (DSCG), in order to obtain more information on the mechanism of textile dust effects. The inhalation of textile dusts causes bronchoconstriction. The airway responses to these dusts are potentiated by propranolol and inhibited by an antihistamine and by ascorbic-acid. Administration of disodium-cromoglycate by spinhaler 30 minutes prior to challenge with hemp dust or hemp dust extract protected some subjects against the airway constrictor effect, mostly those with a large acute reduction in flow rates. Textile dust extracts contain a histamine releasing agent, which explains their airway constrictor effect. This agent is a highly water- soluble, heat-stable, low-molecular-weight compound which has not yet been chemically identified. In the prevention and control of byssinosis, the administration of drugs such as ascorbic-acid or disodium-cromoglycate should be considered in addition to engineering methods.
Keywords
JOCMA7; NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Organic-dusts; Dust-inhalation; Respiratory-system-disorders; Vitamins; Respiratory-functions; Medical-treatment; Control-measures; Preventive-medicine; Antihistamines; Pharmacology
Contact
John B Pierce Fdn Lab John B Pierce Fdn Lab 290 Congress Avenue New Haven, Conn 06519
CODEN
JOCMA7
CAS No.
318-98-9
Publication Date
19750601
Document Type
Journal Article
Funding Amount
513539.00
Funding Type
Grant
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00304
Issue of Publication
6
ISSN
0096-1736
Priority Area
Pulmonary-system-disorders; Respiratory-system-disorders
Source Name
Journal of Occupational Medicine
State
CT
Performing Organization
John B Pierce Fdn of Conn Inc, New Haven, Connecticut
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