Development of biologic standards for trichloroethylene.
Stewart-RD; Hake-CL; Peterson-JE; Forster-HV; Newton-PE; Soto-RJ; Lebrun-AJ
Behavioral Toxicology: Early Detection of Occupational Hazards. Xintaras C, Johnson BL, De Groot I, eds., Washington, DC: National Institute for Occupational Safety and Health, (NIOSH) 74-126, 1974 Jan; :81-91
Male and female human beings are exposed to 20, 100, and 200 parts per million (ppm) trichloroethylene (TCE) (79016) vapor for five consecutive days, to establish the basis for a biologic test through expired breath data, and to study TCE's effects on cognitive and behavioral tasks. Post-exposure TCE breath decay curves are constructed from the data obtained from the volunteers exposed to the three vapor concentrations for three different intervals of time. Exposure to TCE, 100 ppm or greater for 7.5 hours daily produces an alteration in the visual evoked response (VER) of one of three males and all female subjects. Decrements in task performance are observed in two tests: Flanagan coordination and the random number inspection. No dose-response effect is observed.
NIOSH-Contract; Contract-099-72-0084; Chlorinated-hydrocarbons; Toxic-substances; Organic-solvents; Analytical-methods; Safety-standards; Threshold-limit-values; Human-performance; Nervous-system-disorders
Xintaras-C; Johnson-BL; De Groot-I
Behavioral Toxicology: Early Detection of Occupational Hazards
The Medical College of Wisconsin, Department of Environmental Medicine