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Block of neuromuscular transmission by methyl mercury.

Authors
Barrett-JN; Botz-D; Chang-DB
Source
Behavioral Toxicology: Early Detection of Occupational Hazards. Xintaras C, Johnson BL, De Groot I, eds., Washington, DC: National Institute for Occupational Safety and Health, (NIOSH) 74-126, 1974 Jan; :277-284
Link
NIOSHTIC No.
00047824
Abstract
Low concentrations of free methyl mercury (1-3 ppm) irreversibly block synaptic transmission in an isolated frog neuromuscular preparation. The time to block decreases with increasing methyl mercury concentration and with increasing temperature. This block of transmission is due to failure of the presynaptic nerve action potential to propagate to the nerve terminals. The spontaneous release of acetylcholine from nerve terminals is greatly accelerated by methyl mercury, suggesting that methyl mercury depolarizes the presynaptic nerve terminals. Higher doses of methyl mercury (10 ppm) significantly reduce the recorded resting potential of muscle fibers.
Keywords
Alkyl-mercurial; Mercury-poisoning; Metal-poisoning; Organomercury-compounds; Neuromuscular-disorders
CAS No.
51-84-3; 7439-97-6
Publication Date
19740101
Document Type
Conference/Symposia Proceedings
Editors
Xintaras-C; Johnson-BL; De Groot-I
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00427
Source Name
Behavioral Toxicology: Early Detection of Occupational Hazards
State
OH; WA
Performing Organization
University of Washington
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