Chromium complexes with proteins and mucopolysaccharides and their relationship to chromium allergy in sensitized guinea pigs.
Katz-SA; Scheiner-DM; Klein-AW; Samitz-MH
Environ Res 1974 Apr; 7(2):212-219
An experimental study is presented on chromium complexes with proteins and mucopolysaccharides and their relationship to chromium allergy in sensitized guinea pigs. Purified chromium complexes, prepared from chromium (III) and guinea pig serum albumin, guinea pig gamma globulin, heparin, chondroitin sulfate, protein, or mucopolysaccharide, and containing no free chromium were injected intradermally into albino guinea pigs previously sensitized to chromium. The guinea pigs were observed for chromium allergy reactions. The chromium-albumin complex was the only complex studied that produced a significant incidence of allergic reactions indicating albumin as a possible carrier for chromium in the allergic response mechanism.
NIOSH-Publication; NIOSH-Grant; Dermatology; Dermatitis; Immunology; Dialysis; Metals; Sensitization; Hypersensitivity; PM9007834; PM9006535; PM9007287; PM9005496
Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
University of Pennsylvania, Philadelphia, Pennsylvania