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Chromium complexes with proteins and mucopolysaccharides and their relationship to chromium allergy in sensitized guinea pigs.

Authors
Katz-SA; Scheiner-DM; Klein-AW; Samitz-MH
Source
Environ Res 1974 Apr; 7(2):212-219
NIOSHTIC No.
00043553
Abstract
An experimental study is presented on chromium complexes with proteins and mucopolysaccharides and their relationship to chromium allergy in sensitized guinea pigs. Purified chromium complexes, prepared from chromium (III) and guinea pig serum albumin, guinea pig gamma globulin, heparin, chondroitin sulfate, protein, or mucopolysaccharide, and containing no free chromium were injected intradermally into albino guinea pigs previously sensitized to chromium. The guinea pigs were observed for chromium allergy reactions. The chromium-albumin complex was the only complex studied that produced a significant incidence of allergic reactions indicating albumin as a possible carrier for chromium in the allergic response mechanism.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatology; Dermatitis; Immunology; Dialysis; Metals; Sensitization; Hypersensitivity; PM9007834; PM9006535; PM9007287; PM9005496
Contact
Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
CODEN
ENVRAL
CAS No.
7440-47-3
Publication Date
19740401
Document Type
Journal Article
Funding Amount
143667.00
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00303
Issue of Publication
2
ISSN
0013-9351
Priority Area
Dermatitis
Source Name
Environmental Research
State
PA
Performing Organization
University of Pennsylvania, Philadelphia, Pennsylvania
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