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Interaction of metals and minerals in carcinogenesis.

Authors
Cralley-LJ; Sunderman-FW Jr.
Source
Transactions of the 34th Annual Meeting of the American Conference of Governmental Industrial Hygienists, May 14-19, 1972 1972 May; :80-90
Link
NIOSHTIC No.
00041664
Abstract
The results of an experimental study are presented in which rats were administered intramuscular injections of nickel-sulfide (1344496) alone, elemental copper (7440508), chromium (7440473), manganese (7439965), or aluminum (7429905) as controls; or combinations of these metals added to nickel-sulfide to determine the capability of the metals to influence the induction of tumors by nickel-sulfide. Seventeen months after injection of the designated dose combinations, of rats injected with nickel-sulfide alone, 91.7 percent had tumors at the site of injection with a median latency for appearance of the tumors of 289 days; of rats injected with elemental copper (7440508) added to nickel-sulfide, 100 percent had tumors at the injection site with a median latency for tumor appearance of 281 days; of rats injected with elemental chromium (7440473) added to nickel-sulfide, 95.8 percent had tumors at the injection site with a median latency of 260 days; of rats injected with aluminum-oxide (1344281) added to nickel-sulfide, 91.7 percent had tumors at the injection site with a median latency of 328 days; of rats injected with elemental manganese (7439965) added to nickel- sulfide, 62.5 percent had tumors at the injection site with a median latency of 387 days; of rats injected with elemental chromium (7440473) and manganese (7439965) added to nickel-sulfide, only 12.5 percent had tumors at the injection site with the appearance of three tumors 398, 468, and 496 days, respectively, after injection. The results give strong support to the existence of an electromotive interaction of metals on nickel- sulfide. Additionally discussed are the possible roles of metal interaction in the carcinogenic mechanism of asbestos (1332214).
Keywords
Tumorigenesis; Carcinogenesis; Carcinogens; Metals
CAS No.
1344-49-6; 7440-50-8; 7440-47-3; 7439-96-5; 7429-90-5; 7440-50-8; 7440-47-3; 1344-28-1; 7439-96-5; 7440-47-3; 7439-96-5; 1332-21-4
Publication Date
19720519
Document Type
Conference/Symposia Proceedings
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Source Name
Transactions of the 34th Annual Meeting of the American Conference of Governmental Industrial Hygienists, May 14-19, 1972
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