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Twenty-four hour pattern of luteinizing hormone secretion in normal men with sleep stage recording.

Authors
Boyar-R; Perlow-M; Hellman-L; Kapen-S; Weitzman-E
Source
J Clin Endocrinol Metab 1972 Jul; 35(1):73-81
NIOSHTIC No.
00038665
Abstract
Plasma luteinizing-hormone (9002679) was measured by radioimmunoassay for 24 hours in 5 normal adult men. During the nocturnal sleep period, polygraphic monitoring of sleep stages was carried out. All 5 subjects showed episodic secretion of luteinizing-hormone characterized by rapid rises and the declining slopes approximated the half-life of luteinizing-hormone. Calculation of luteinizing hormone "half-life" from the declining phase of the luteinizing hormone secretory episodes gave variable estimates within subjects and between subjects. The longer estimates calculated by this method, contrasted with previous studies where half-life was determined directly by the measurement of luteinizing-hormone disappearance is probably the result of small amounts of luteinizing-hormone being secreted during the declining phase of the secretory episode. This study failed to show a 24-hour luteinizing-hormone rhythm or relationship of luteinizing-hormone secretory activity to the sleep-wake cycle. Comparison between the luteinizing-hormone and cortisol (50237) secretory patterns was made in an attempt to characterize differences in endocrine control mechanisms.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Endocrine-function; Pituitary-functions; Physiological-factors; Physiological-response; Immunological-techniques; Biological-rhythms
Contact
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
CODEN
JCEMAZ
CAS No.
9002-67-9; 50-23-7
Publication Date
19720701
Document Type
Journal Article
Funding Amount
346110
Funding Type
Grant
Fiscal Year
1972
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00331
Issue of Publication
1
ISSN
0021-972X
Priority Area
Grants-other
Source Name
Journal of Clinical Endocrinology and Metabolism
State
NY
Performing Organization
Montefiore Hospital and Medical Center, New York, New York
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