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Studies of endocrine function in "isolated" gonadotropin deficiency.

Authors
Boyar-RM; Finkelstein-JW; Witkin-M; Kapen-S; Weitzman-E; Hellman-L
Source
J Clin Endocrinol Metab 1973 Jan; 36(1):64-72
NIOSHTIC No.
00038662
Abstract
Six chromatin-negative young men with hypogonadotropic hypogonadism were studied in an attempt to clarify and define the endocrine abnormalities responsible for this disorder. Five of the six patients had associated congenital anomalies involving the skeletal system or midline facial structures. Pituitary function studies showed normal thyroid and adrenal function. Evaluation of pituitary- gonadal function showed normal prepubertal concentrations of luteinizing-hormone (9002679), follicle-stimulating-hormone (9002759) and testosterone (58220). These observations show that hypogonadotropic hypogonadism is associated with a high frequency of congenital abnormalities, subnormal sleep-mediated growth-hormone (9002726) release, plasma luteinizing-hormone and follicle- stimulating-hormone concentrations indistinguishable from normal prepubertal boys and normal plasma testosterone responses to long human chorionic-gonadotropin (9002613) treatment.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Endocrine-system-disorders; Endocrine-function; Musculoskeletal-system-disorders; Sex-hormones; Growth-disorders; Gonadal-functions; Reproductive-system; Pituitary-functions; Reproduction-hormones
Contact
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
CODEN
JCEMAZ
CAS No.
9002-67-9; 9002-75-9; 58-22-0; 9002-72-6; 9002-61-3
Publication Date
19730101
Document Type
Journal Article
Funding Amount
346110.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00331
Issue of Publication
1
ISSN
0021-972
Priority Area
Grants-other; Musculoskeletal-system-disorders
Source Name
Journal of Clinical Endocrinology and Metabolism
State
NY
Performing Organization
Montefiore Hospital and Medical Center, New York, New York
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