Studies of endocrine function in "isolated" gonadotropin deficiency.
Boyar-RM; Finkelstein-JW; Witkin-M; Kapen-S; Weitzman-E; Hellman-L
J Clin Endocrinol Metab 1973 Jan; 36(1):64-72
Six chromatin-negative young men with hypogonadotropic hypogonadism were studied in an attempt to clarify and define the endocrine abnormalities responsible for this disorder. Five of the six patients had associated congenital anomalies involving the skeletal system or midline facial structures. Pituitary function studies showed normal thyroid and adrenal function. Evaluation of pituitary- gonadal function showed normal prepubertal concentrations of luteinizing-hormone (9002679), follicle-stimulating-hormone (9002759) and testosterone (58220). These observations show that hypogonadotropic hypogonadism is associated with a high frequency of congenital abnormalities, subnormal sleep-mediated growth-hormone (9002726) release, plasma luteinizing-hormone and follicle- stimulating-hormone concentrations indistinguishable from normal prepubertal boys and normal plasma testosterone responses to long human chorionic-gonadotropin (9002613) treatment.
NIOSH-Publication; NIOSH-Grant; Grants-other; Endocrine-system-disorders; Endocrine-function; Musculoskeletal-system-disorders; Sex-hormones; Growth-disorders; Gonadal-functions; Reproductive-system; Pituitary-functions; Reproduction-hormones
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
9002-67-9; 9002-75-9; 58-22-0; 9002-72-6; 9002-61-3
Journal of Clinical Endocrinology and Metabolism
Montefiore Hospital and Medical Center, New York, New York