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Implantation of exogenous enzymatic activity in isolated alveolar macrophages.

Authors
Theodore-J; Acevedo-JC; Robin-ED
Source
Science 1972 Dec; 178(4067):1302-1304
NIOSHTIC No.
00038657
Abstract
Alveolar macrophages are found to acquire the capacity to oxidize uric-acid (69932) after exposure to uricase. This is presumed to have resulted from intracellular incorporation of the exogenous enzyme by endocytosis. This approach may provide a general method for; testing regulatory biochemical mechanism; therapeutic replacement of deficient regulatory macromolecules; and studying environmental factors that produce genetic alterations.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Enzyme-activity; Mutation; Cytology
Contact
Physiology Stanford University Sch of Med Department of Medicine Palo Alto, Calif
CODEN
SCIEAS
CAS No.
69-93-2
Publication Date
19721222
Document Type
Journal Article
Funding Amount
668550.00
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00352
Issue of Publication
4067
ISSN
0036-8075
Priority Area
Pulmonary-system-disorders
Source Name
Science
State
CA
Performing Organization
Stanford University, Stanford, California
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