Implantation of exogenous enzymatic activity in isolated alveolar macrophages.
Theodore-J; Acevedo-JC; Robin-ED
Science 1972 Dec; 178(4067):1302-1304
Alveolar macrophages are found to acquire the capacity to oxidize uric-acid (69932) after exposure to uricase. This is presumed to have resulted from intracellular incorporation of the exogenous enzyme by endocytosis. This approach may provide a general method for; testing regulatory biochemical mechanism; therapeutic replacement of deficient regulatory macromolecules; and studying environmental factors that produce genetic alterations.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Enzyme-activity; Mutation; Cytology
Physiology Stanford University Sch of Med Department of Medicine Palo Alto, Calif
Stanford University, Stanford, California